Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 17/20 | 0.56 |
| ▸ | JAK3 | P52333 | 7/20 | 0.56 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.56 |
| ▸ | FLT3 | P36888 | 2/20 | 0.56 |
| ▸ | PLK4 | O00444 | 2/20 | 0.56 |
| ▸ | IKBKB | O14920 | 1/20 | 0.56 |
| ▸ | KIT | P10721 | 1/20 | 0.56 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.56 |
| ▸ | FLT1 | P17948 | 1/20 | 0.56 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.56 |
| ▸ | JAK1 | P23458 | 1/20 | 0.56 |
| ▸ | TYK2 | P29597 | 1/20 | 0.56 |
| ▸ | FLT4 | P35916 | 1/20 | 0.56 |
| ▸ | KDR | P35968 | 1/20 | 0.56 |
| ▸ | MAP3K9 | P80192 | 1/20 | 0.56 |
| ▸ | CIT | O14578 | 1/20 | 0.56 |
| ▸ | GAK | O14976 | 1/20 | 0.56 |
| ▸ | BUB1 | O43683 | 1/20 | 0.56 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.56 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4378428 | 0.86 | JAK2 (0.79) | JAK2JAK3PDGFRBFLT3PLK4 | |
| SCHEMBL4382174 | 0.86 | JAK2 (0.79) | JAK2JAK3PDGFRBFLT3PLK4 | |
| SCHEMBL4378779 | 0.86 | JAK2 (0.79) | JAK2JAK3PDGFRBFLT3PLK4 | |
| SCHEMBL4378783 | 0.85 | JAK2 (0.57) | JAK2JAK3PDGFRBFLT3PLK4 | |
| SCHEMBL4378431 | 0.85 | JAK2 (0.57) | JAK2JAK3PDGFRBFLT3PLK4 | |
| SCHEMBL4382690 | 0.81 | JAK2 (0.58) | JAK2JAK3IKBKB | |
| SCHEMBL8239814 | 0.80 | PLK4 (0.68) | JAK2JAK3PDGFRBFLT3PLK4 | |
| SCHEMBL4382459 | 0.79 | JAK2 (0.59) | JAK2JAK3IKBKBJAK1TYK2 | |
| SCHEMBL4383881 | 0.77 | JAK2 (0.78) | JAK2JAK3PLK4JAK1TYK2 | |
| SCHEMBL4381994 | 0.77 | JAK2 (0.76) | JAK2JAK3PDGFRBFLT3PLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007089768-A2 | 4-ARYL-2-AMINO-PYRIMIDINES OR 4-ARYL-2-AMINOALKYL-PYRIMIDINES AS JAK-2 MODULATORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | EXELIXIS, INC. (US) | 2007-08-09 | — | — | WO | disclosed |