Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 6/20 | 0.84 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.84 |
| ▸ | MAPT | P10636 | 5/20 | 0.84 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.84 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.84 |
| ▸ | HTT | P42858 | 1/20 | 0.84 |
| ▸ | LMNA | P02545 | 1/20 | 0.74 |
| ▸ | RAB9A | P51151 | 1/20 | 0.74 |
| ▸ | ABL1 | P00519 | 2/20 | 0.68 |
| ▸ | RIN1 | Q13671 | 2/20 | 0.68 |
| ▸ | TSHR | P16473 | 1/20 | 0.68 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.66 |
| ▸ | PKM | P14618 | 1/20 | 0.61 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.61 |
| ▸ | LTC4S | Q16873 | 1/20 | 0.59 |
| ▸ | SERPINE1 | P05121 | 3/20 | 0.59 |
| ▸ | AKR1C4 | P17516 | 2/20 | 0.59 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.59 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.59 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29367215 | 0.98 | MEN1 (0.82) | MEN1KMT2AMAPTTDP1ALDH1A1 | |
| SCHEMBL2810656 | 0.98 | MEN1 (0.82) | MEN1KMT2AMAPTTDP1ALDH1A1 | |
| SCHEMBL6096421 | 0.93 | MEN1 (0.74) | MEN1KMT2AMAPTTDP1ALDH1A1 | |
| SCHEMBL20513012 | 0.91 | MAPT (0.79) | MEN1KMT2AMAPTTDP1ALDH1A1 | |
| SCHEMBL4157251 | 0.89 | MAPT (0.69) | MEN1KMT2AMAPTTDP1ALDH1A1 | |
| SCHEMBL9973844 | 0.89 | MEN1 (0.69) | MEN1KMT2AMAPTTDP1ALDH1A1 | |
| SCHEMBL6091702 | 0.86 | MEN1 (0.78) | MEN1KMT2AMAPTTDP1ALDH1A1 | |
| SCHEMBL9973842 | 0.86 | MAPT (0.66) | MEN1KMT2AMAPTTDP1ALDH1A1 | |
| SCHEMBL14075225 | 0.86 | MEN1 (0.66) | MEN1KMT2AMAPTTDP1ALDH1A1 | |
| SCHEMBL4669087 | 0.86 | MEN1 (0.65) | MEN1KMT2AMAPTTDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9198891-B2 | Method of treating cancer by inhibition of protein kinase-like endoplasmic reticulum protein kinase | NEW YORK UNIVERSITY (US) | 2015-12-01 | — | — | US | disclosed |
| US-20110288083-A1 | METHOD OF TREATING CANCER BY INHIBITION OF PROTEIN KINASE-LIKE ENDOPLASMIC RETICULUM PROTEIN KINASE | NEW YORK UNIVERSITY (US) | 2011-11-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110288083-A1 | METHOD OF TREATING CANCER BY INHIBITION OF PROTEIN KINASE-LIKE ENDOPLASMIC RETICULUM PROTEIN KINASE | ERN1, ERN2, EEF2K | MEN1 3488/4885KMT2A 3197/4885MAPT 2510/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.