Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 12/20 | 0.36 |
| ▸ | BCHE | P06276 | 11/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.33 |
| ▸ | KDM5A | P29375 | 2/20 | 0.33 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL380215 | 0.95 | HDAC6 (0.43) | HDAC6HDAC1HDAC2ACHEBCHE | |
| SCHEMBL499576 | 0.89 | HDAC6 (0.38) | HDAC6HDAC1HDAC2CA14 | |
| SCHEMBL9354449 | 0.81 | TSHR (0.45) | HDAC6HDAC1HDAC2CA14KDM5A | |
| SCHEMBL1249634 | 0.80 | EPHX2 (0.43) | HDAC6HDAC1HDAC2CA14EPHX2 | |
| SCHEMBL21235768 | 0.80 | HDAC6 (0.42) | HDAC6HDAC1HDAC2ACHEBCHE | |
| SCHEMBL9227134 | 0.80 | HDAC6 (0.46) | HDAC6HDAC1HDAC2ACHEBCHE | |
| SCHEMBL9354670 | 0.80 | HDAC6 (0.44) | HDAC6HDAC1HDAC2ACHEBCHE | |
| SCHEMBL903563 | 0.79 | TSHR (0.44) | HDAC6HDAC1HDAC2ACHEBCHE | |
| SCHEMBL31170248 | 0.79 | HDAC6 (0.50) | HDAC6HDAC1HDAC2ACHEBCHE | |
| SCHEMBL23113130 | 0.79 | EPHX2 (0.45) | HDAC6HDAC1HDAC2EPHX2KDM5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007117560-A2 | PIPERIDINE AND MORPHOLINE RENIN INHIBITORS | VITAE PHARMACEUTICALS, INC. (US) | 2007-10-18 | — | — | WO | disclosed |