Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 16/20 | 0.84 |
| ▸ | EPHX1 | P07099 | 7/20 | 0.84 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.64 |
| ▸ | GAA | P10253 | 1/20 | 0.64 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.64 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2717510 | 0.91 | EPHX2 (1.00) | EPHX2EPHX1CYP1A2CYP3A4GAA | |
| SCHEMBL1913735 | 0.84 | EPHX2 (1.00) | EPHX2EPHX1 | |
| SCHEMBL17316257 | 0.84 | EPHX2 (0.83) | EPHX2EPHX1 | |
| SCHEMBL2730200 | 0.83 | EPHX2 (1.00) | EPHX2EPHX1 | |
| SCHEMBL27735940 | 0.83 | EPHX2 (0.69) | EPHX2EPHX1CYP1A2CYP3A4GAA | |
| SCHEMBL4010451 | 0.83 | EPHX2 (0.80) | EPHX2EPHX1 | |
| SCHEMBL3346010 | 0.82 | EPHX2 (1.00) | EPHX2EPHX1 | |
| SCHEMBL2729784 | 0.81 | EPHX2 (1.00) | EPHX2EPHX1CYP1A2CYP3A4GAA | |
| SCHEMBL15335336 | 0.80 | EPHX2 (0.78) | EPHX2EPHX1 | |
| SCHEMBL14984066 | 0.79 | CYP1A2 (1.00) | EPHX2EPHX1CYP1A2CYP3A4GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007106525-A1 | PIPERIDINYL, INDOLYL, PIRINIDYL, MORPHOLINYL AND BENZIMIDAZOLYL UREA DERIVATIVES AS INHIBITORS OF SOLUBLE EPOXIDE HYDROLASE FOR THE TREATMENT OF HYPERTENSION, INFLAMMATIONS AND OTHER DISEASES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2007-09-20 | — | — | WO | disclosed |