Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB1 | P05556 | 19/20 | 0.77 |
| ▸ | ITGA5 | P08648 | 16/20 | 0.77 |
| ▸ | ITGB3 | P05106 | 4/20 | 0.69 |
| ▸ | ITGAV | P06756 | 4/20 | 0.69 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.45 |
| ▸ | ITGB6 | P18564 | 1/20 | 0.45 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.44 |
| ▸ | MDM4 | O15151 | 1/20 | 0.44 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4068226 | 1.00 | ITGB1 (0.77) | ITGB1ITGA5ITGB3ITGAVITGB5 | |
| SCHEMBL8236797 | 0.97 | ITGB1 (0.81) | ITGB1ITGA5ITGB3ITGAVITGB5 | |
| SCHEMBL4067367 | 0.97 | ITGB1 (0.81) | ITGB1ITGA5ITGB3ITGAVITGB5 | |
| SCHEMBL14270716 | 0.91 | ITGB1 (0.83) | ITGB1ITGA5ITGB3ITGAVITGB5 | |
| SCHEMBL4066779 | 0.90 | ITGB1 (0.94) | ITGB1ITGA5ITGB3ITGAVITGA4 | |
| SCHEMBL8232202 | 0.90 | ITGB1 (0.94) | ITGB1ITGA5ITGB3ITGAVITGA4 | |
| SCHEMBL20025129 | 0.89 | ITGB1 (0.70) | ITGB1ITGA5ITGB3ITGAVITGB5 | |
| SCHEMBL8234167 | 0.89 | ITGB1 (0.65) | ITGB1ITGA5ITGB3ITGAVITGA4 | |
| SCHEMBL4068703 | 0.89 | ITGB1 (0.65) | ITGB1ITGA5ITGB3ITGAVITGA4 | |
| SCHEMBL8234588 | 0.89 | ITGB1 (0.64) | ITGB1ITGA5ITGB3ITGAVITGA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007141473-A1 | N-(BENZOYL)-O- [2- (PYRIDIN- 2 -YLAMINO) ETHYL] -L-TYROSINE DERIVATIVES AND RELATED COMPOUNDS AS A5B1 ANTAGONISTS FOR THE TREATMENT OF SOLID TUMORS | ASTRAZENECA AB (SE) | 2007-12-13 | — | — | WO | disclosed |