Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 11/20 | 1.00 |
| ▸ | HDAC1 | Q13547 | 14/20 | 0.69 |
| ▸ | HDAC2 | Q92769 | 8/20 | 0.63 |
| ▸ | HDAC3 | O15379 | 6/20 | 0.63 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.63 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.63 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.63 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.63 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.63 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.63 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13783904 | 1.00 | HDAC8 (1.00) | HDAC8HDAC1HDAC2HDAC3HDAC6 | |
| SCHEMBL3383908 | 0.91 | HDAC8 (0.83) | HDAC8HDAC1HDAC2HDAC3HDAC6 | |
| SCHEMBL3383906 | 0.91 | HDAC8 (0.83) | HDAC8HDAC1HDAC2HDAC3HDAC6 | |
| SCHEMBL6387219 | 0.86 | HDAC8 (0.75) | HDAC8HDAC1HDAC2HDAC3HDAC6 | |
| SCHEMBL6387212 | 0.86 | HDAC8 (0.75) | HDAC8HDAC1HDAC2HDAC3HDAC6 | |
| SCHEMBL1520838 | 0.82 | HDAC1 (1.00) | HDAC8HDAC1HDAC2HDAC3HDAC6 | |
| SCHEMBL3383159 | 0.81 | HDAC8 (1.00) | HDAC8HDAC1HDAC2HDAC3HDAC6 | |
| SCHEMBL3383152 | 0.81 | HDAC8 (1.00) | HDAC8HDAC1HDAC2HDAC3HDAC6 | |
| SCHEMBL3383163 | 0.81 | HDAC8 (1.00) | HDAC8HDAC1HDAC2HDAC3HDAC6 | |
| SCHEMBL8228945 | 0.79 | HDAC1 (0.73) | HDAC8HDAC1HDAC2HDAC3HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8759400-B2 | Histone deacetylase inhibitors for enhancing activity of antifungal agents | METHYLGENE INC. (CA) | 2014-06-24 | — | — | US | disclosed |
| US-8759400-B2 | Histone deacetylase inhibitors for enhancing activity of antifungal agents | METHYLGENE INC. (CA) | 2014-06-24 | — | — | US | disclosed |
| WO-2012021982-A1 | ANTIFUNGAL AGENTS AND USES THEREOF | METHYLGENE INC. (CA) | 2012-02-23 | — | — | WO | disclosed |
| US-20090181971-A1 | Inhibitors of Histone Deacetylase | METHYLGENE INC. | 2009-07-16 | — | — | US | disclosed |
| US-7288567-B2 | Inhibitors of histone deacetylase | METHYLGENE INC. (CA) | 2007-10-30 | — | — | US | disclosed |
| US-7288567-B2 | Inhibitors of histone deacetylase | METHYLGENE INC. (CA) | 2007-10-30 | — | — | US | disclosed |
| US-20070197550-A1 | Histone deacetylase inhibitors for enhancing activity of antifungal agents | 92229129 QUEBEC INC. (CA) | 2007-08-23 | — | — | US | disclosed |
| US-20070197550-A1 | Histone deacetylase inhibitors for enhancing activity of antifungal agents | 92229129 QUEBEC INC. (CA) | 2007-08-23 | — | — | US | disclosed |
| WO-2007072179-A2 | HISTONE DEACETYLASE INHIBITORS FOR ENHANCING ACTIVITY OF ANTIFUNGAL AGENTS | METHYLGENE, INC. (CA) | 2007-06-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070197550-A1 | Histone deacetylase inhibitors for enhancing activity of antifungal agents | HDAC1, HDAC5, HDAC7 | HDAC8 6/4885HDAC1 1/4885HDAC2 4/4885 |
| US-20090181971-A1 | Inhibitors of Histone Deacetylase | HDAC1, HDAC5, HDAC3 | HDAC8 9/4885HDAC1 1/4885HDAC2 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.