⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17472514 | 0.82 | — | — | |
| SCHEMBL2734320 | 0.71 | — | — | |
| SCHEMBL4508394 | 0.68 | — | — | |
| SCHEMBL10531763 | 0.68 | — | — | |
| SCHEMBL4526771 | 0.68 | — | — | |
| SCHEMBL18775103 | 0.68 | — | — | |
| Ethylene Thiourea SCHEMBL41176 | 0.66 | — | — | |
| Ethylene Thiourea SCHEMBL6245350 | 0.64 | SMN1; SMN2 (0.55) | — | |
| Ethylene Thiourea SCHEMBL3134739 | 0.63 | — | — | |
| Ethylene Thiourea SCHEMBL22347146 | 0.63 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1863477-B1 | 3,4-SUBSTITUTED PYRROLIDINE DERIVATIVES FOR THE TREATMENT OF HYPERTENSION | NOVARTIS AG (CH) | 2010-11-03 | — | — | EP | disclosed |
| EP-1833816-B1 | SUBSTITUTED PIPERIDINES AS RENIN INHIBITORS | NOVARTIS AG (CH) | 2009-11-11 | — | — | EP | disclosed |
| WO-2007077005-A1 | 3 , 5-SUBSTITΓUED PIPERIDINE COMPOUNDS AS RENIN INHIBITORS | NOVARTIS AG (CH) | 2007-07-12 | — | — | WO | disclosed |