Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 20/20 | 0.57 |
| ▸ | JAK3 | P52333 | 17/20 | 0.57 |
| ▸ | JAK1 | P23458 | 8/20 | 0.57 |
| ▸ | TYK2 | P29597 | 5/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | NCOR1 | O75376 | 1/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.50 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.49 |
| ▸ | PLK4 | O00444 | 1/20 | 0.49 |
| ▸ | CIT | O14578 | 1/20 | 0.49 |
| ▸ | GAK | O14976 | 1/20 | 0.49 |
| ▸ | OPA1 | O60313 | 1/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.49 |
| ▸ | STK16 | O75716 | 1/20 | 0.49 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.49 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.49 |
| ▸ | CDK2 | P24941 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4384135 | 0.89 | JAK2 (0.56) | JAK2JAK3JAK1TYK2HDAC1 | |
| SCHEMBL4377714 | 0.87 | JAK2 (0.75) | JAK2JAK3JAK1TYK2HDAC1 | |
| SCHEMBL4383750 | 0.80 | JAK2 (0.78) | JAK2JAK3JAK1TYK2HDAC1 | |
| SCHEMBL4833052 | 0.79 | JAK2 (0.72) | JAK2JAK3JAK1TYK2HDAC1 | |
| SCHEMBL4383496 | 0.79 | JAK2 (0.59) | JAK2JAK3JAK1TYK2HDAC1 | |
| SCHEMBL4390385 | 0.79 | JAK2 (0.80) | JAK2JAK3JAK1TYK2HDAC1 | |
| SCHEMBL4379589 | 0.78 | JAK2 (0.62) | JAK2JAK3JAK1TYK2HDAC1 | |
| SCHEMBL8236877 | 0.78 | JAK2 (0.75) | JAK2JAK3JAK1TYK2HDAC1 | |
| SCHEMBL4374484 | 0.78 | JAK2 (0.75) | JAK2JAK3JAK1TYK2HDAC1 | |
| SCHEMBL12921641 | 0.78 | JAK2 (0.55) | JAK2JAK3JAK1TYK2HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007089768-A2 | 4-ARYL-2-AMINO-PYRIMIDINES OR 4-ARYL-2-AMINOALKYL-PYRIMIDINES AS JAK-2 MODULATORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | EXELIXIS, INC. (US) | 2007-08-09 | — | — | WO | disclosed |