Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 15/20 | 0.67 |
| ▸ | JAK3 | P52333 | 2/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.52 |
| ▸ | SYK | P43405 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | LDLR | P01130 | 1/20 | 0.46 |
| ▸ | KIT | P10721 | 1/20 | 0.46 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4376382 | 0.89 | JAK2 (0.64) | JAK2JAK3HDAC1HDAC6SYK | |
| SCHEMBL4385265 | 0.88 | JAK2 (0.70) | JAK2JAK3HDAC1HDAC6KDM4E | |
| SCHEMBL4377917 | 0.87 | JAK2 (0.68) | JAK2JAK3HDAC1HDAC6LDLR | |
| SCHEMBL4380211 | 0.85 | JAK2 (0.72) | JAK2JAK3HDAC1HDAC6KDM4E | |
| SCHEMBL4381477 | 0.84 | JAK2 (0.73) | JAK2JAK3HDAC1HDAC6SYK | |
| SCHEMBL4378602 | 0.84 | JAK2 (0.65) | JAK2JAK3HDAC1HDAC6SYK | |
| SCHEMBL4383246 | 0.83 | JAK2 (0.64) | JAK2JAK3HDAC1HDAC6KDM4E | |
| SCHEMBL4382746 | 0.83 | JAK2 (0.71) | JAK2JAK3HDAC1HDAC6SYK | |
| SCHEMBL4380361 | 0.83 | JAK2 (0.71) | JAK2JAK3HDAC1HDAC6SYK | |
| SCHEMBL4385527 | 0.82 | JAK2 (0.76) | JAK2JAK3HDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007089768-A2 | 4-ARYL-2-AMINO-PYRIMIDINES OR 4-ARYL-2-AMINOALKYL-PYRIMIDINES AS JAK-2 MODULATORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | EXELIXIS, INC. (US) | 2007-08-09 | — | — | WO | disclosed |