Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1B | Q00975 | 17/20 | 0.51 |
| ▸ | NR1I2 | O75469 | 8/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8234188 | 0.88 | CACNA1B (0.65) | CACNA1BNR1I2CYP3A4ALDH1A1 | |
| SCHEMBL3486080 | 0.86 | CACNA1B (0.46) | CACNA1BNR1I2CYP3A4USP2ALDH1A1 | |
| SCHEMBL3485614 | 0.85 | GAA (0.50) | CACNA1BNR1I2CYP3A4USP2ALDH1A1 | |
| SCHEMBL3765000 | 0.85 | CACNA1B (0.48) | CACNA1BNR1I2CYP3A4GAAHPGD | |
| SCHEMBL3486010 | 0.85 | CACNA1B (0.46) | CACNA1BNR1I2CYP3A4USP2ALDH1A1 | |
| SCHEMBL4389619 | 0.85 | CACNA1B (0.49) | CACNA1BNR1I2CYP3A4USP2ALDH1A1 | |
| SCHEMBL3485902 | 0.84 | CACNA1B (0.46) | CACNA1BNR1I2CYP3A4USP2ALDH1A1 | |
| SCHEMBL3486052 | 0.84 | CACNA1B (0.49) | CACNA1BNR1I2CYP3A4USP2ALDH1A1 | |
| SCHEMBL3485675 | 0.84 | CACNA1B (0.50) | CACNA1BNR1I2CYP3A4USP2ALDH1A1 | |
| SCHEMBL3763660 | 0.84 | CACNA1B (0.47) | CACNA1BNR1I2CYP3A4GAAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8791264-B2 | Benzenesulfonamide compounds and their use as blockers of calcium channels | PURDUE PHARMA L.P. (US) | 2014-07-29 | — | — | US | disclosed |
| US-8791264-B2 | Benzenesulfonamide compounds and their use as blockers of calcium channels | PURDUE PHARMA L.P. (US) | 2014-07-29 | — | — | US | disclosed |
| US-20100022595-A1 | Benzenesulfonamide Compounds and Their Use as Blockers of Calcium Channels | PURDUE PHARMA L.P. (CT) | 2010-01-28 | — | — | US | disclosed |
| US-20100022595-A1 | Benzenesulfonamide Compounds and Their Use as Blockers of Calcium Channels | PURDUE PHARMA L.P. (CT) | 2010-01-28 | — | — | US | disclosed |
| WO-2007118853-A1 | BENZENESULFONAMIDE COMPOUNDS AND THEIR USE AS BLOCKERS OF CALCIUM CHANNELS | EURO-CELTIQUE S.A. (LU) | 2007-10-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100022595-A1 | Benzenesulfonamide Compounds and Their Use as Blockers of Calcium Channels | CACNA1A, CACNA1E, CACNA1B | CACNA1B 3/4885NR1I2 1340/4885CYP3A4 771/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.