Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 15/20 | 0.68 |
| ▸ | JAK3 | P52333 | 7/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | GFER | P55789 | 1/20 | 0.54 |
| ▸ | JAK1 | P23458 | 3/20 | 0.53 |
| ▸ | MOK | Q9UQ07 | 1/20 | 0.52 |
| ▸ | TYK2 | P29597 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | BRAF | P15056 | 1/20 | 0.51 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.50 |
| ▸ | FLT3 | P36888 | 2/20 | 0.50 |
| ▸ | IKBKB | O14920 | 1/20 | 0.50 |
| ▸ | KIT | P10721 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4374533 | 0.96 | JAK2 (0.73) | JAK2JAK3JAK1MOKTYK2 | |
| SCHEMBL4391267 | 0.86 | JAK2 (0.73) | JAK2JAK3JAK1MOKTYK2 | |
| SCHEMBL8241137 | 0.85 | JAK2 (0.72) | JAK2JAK3CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL4390308 | 0.81 | JAK2 (1.00) | JAK2JAK3JAK1TYK2PDGFRB | |
| SCHEMBL8076812 | 0.80 | JAK2 (0.56) | JAK2JAK3JAK1TYK2MAPT | |
| SCHEMBL13588580 | 0.80 | MOK (0.61) | JAK2JAK3MOKKDM4EMEN1 | |
| SCHEMBL4381056 | 0.80 | JAK2 (1.00) | JAK2JAK3CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL4385532 | 0.80 | JAK2 (1.00) | JAK2JAK3CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL8084906 | 0.79 | MOK (0.60) | JAK2JAK3MOKKDM4EMEN1 | |
| SCHEMBL4376882 | 0.79 | JAK2 (0.98) | JAK2JAK3JAK1TYK2PDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007089768-A2 | 4-ARYL-2-AMINO-PYRIMIDINES OR 4-ARYL-2-AMINOALKYL-PYRIMIDINES AS JAK-2 MODULATORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | EXELIXIS, INC. (US) | 2007-08-09 | — | — | WO | disclosed |