Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 15/20 | 0.59 |
| ▸ | JAK3 | P52333 | 1/20 | 0.58 |
| ▸ | HDAC1 | Q13547 | 7/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 0.56 |
| ▸ | PLK1 | P53350 | 1/20 | 0.52 |
| ▸ | SYK | P43405 | 1/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.48 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.48 |
| ▸ | ABL1 | P00519 | 1/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.48 |
| ▸ | BCR | P11274 | 1/20 | 0.48 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4390282 | 0.91 | JAK2 (0.61) | JAK2JAK3HDAC1HDAC6PLK1 | |
| SCHEMBL4378641 | 0.90 | JAK2 (0.58) | JAK2JAK3HDAC1HDAC6PLK1 | |
| SCHEMBL4381641 | 0.90 | JAK2 (0.65) | JAK2JAK3HDAC1HDAC6PLK1 | |
| SCHEMBL28775827 | 0.84 | JAK2 (0.64) | JAK2JAK3HDAC1HDAC6PLK1 | |
| SCHEMBL4374510 | 0.84 | JAK2 (0.63) | JAK2JAK3HDAC1HDAC6PLK1 | |
| SCHEMBL4383514 | 0.83 | JAK2 (0.65) | JAK2JAK3HDAC1HDAC6PLK1 | |
| SCHEMBL4376979 | 0.83 | JAK2 (0.62) | JAK2JAK3HDAC1HDAC6PLK1 | |
| SCHEMBL4376497 | 0.82 | JAK2 (0.72) | JAK2JAK3HDAC1HDAC6PLK1 | |
| SCHEMBL4375557 | 0.79 | JAK2 (0.79) | JAK2JAK3HDAC1HDAC6PLK1 | |
| SCHEMBL4383223 | 0.78 | JAK2 (0.66) | JAK2JAK3HDAC1HDAC6PLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007089768-A2 | 4-ARYL-2-AMINO-PYRIMIDINES OR 4-ARYL-2-AMINOALKYL-PYRIMIDINES AS JAK-2 MODULATORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | EXELIXIS, INC. (US) | 2007-08-09 | — | — | WO | disclosed |