Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 20/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 13/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 11/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.52 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.47 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.47 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3091029 | 0.77 | HDAC6 (0.54) | HDAC6HDAC1HDAC4HDAC3HDAC7 | |
| SCHEMBL13154055 | 0.74 | HDAC6 (0.51) | HDAC6HDAC1HDAC4HDAC3HDAC7 | |
| SCHEMBL3094136 | 0.71 | HDAC6 (0.70) | HDAC6HDAC1HDAC4HDAC3HDAC7 | |
| SCHEMBL13154042 | 0.71 | HDAC6 (0.72) | HDAC6HDAC1HDAC4HDAC3HDAC7 | |
| SCHEMBL3094688 | 0.69 | HDAC6 (1.00) | HDAC6HDAC1HDAC4HDAC3 | |
| SCHEMBL3101550 | 0.69 | HDAC6 (0.64) | HDAC6HDAC1HDAC4HDAC3HDAC7 | |
| SCHEMBL3098565 | 0.69 | HDAC6 (1.00) | HDAC6HDAC1HDAC4HDAC3HDAC7 | |
| SCHEMBL3086919 | 0.68 | HDAC6 (1.00) | HDAC6HDAC1HDAC4HDAC3HDAC7 | |
| SCHEMBL3094022 | 0.68 | HDAC6 (0.79) | HDAC6HDAC1HDAC4HDAC3HDAC7 | |
| SCHEMBL3092498 | 0.68 | HDAC6 (0.57) | HDAC6HDAC1HDAC4HDAC3HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007093827-A1 | THIOPHENE AND THIAZOLE SUBSTITUTED TRIFLUOROETHANONE DERIVATIVES AS HISTONE DEACETYLASE (HDAC) INHIBITORS | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2007-08-23 | — | — | WO | disclosed |