Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEAD1 | P28347 | 1/20 | 0.44 |
| ▸ | TEAD3 | Q99594 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 9/20 | 0.43 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.43 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.43 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | HRH2 | P25021 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6726496 | 0.89 | TEAD1 (0.46) | TEAD1TEAD3GPR119NR1H2NR1H3 | |
| SCHEMBL4859274 | 0.87 | TEAD1 (0.45) | TEAD1TEAD3NPC1GPR119NR1H2 | |
| SCHEMBL4859279 | 0.87 | TEAD1 (0.45) | TEAD1TEAD3NPC1GPR119NR1H2 | |
| SCHEMBL4856827 | 0.86 | PDE4B (0.44) | TEAD1TEAD3NPC1GPR119NR1H2 | |
| SCHEMBL4856821 | 0.86 | PDE4B (0.44) | TEAD1TEAD3NPC1GPR119NR1H2 | |
| SCHEMBL4846682 | 0.85 | NR1H2 (0.44) | NPC1NR1H2NR1H3KDM4EALDH1A1 | |
| SCHEMBL4846692 | 0.85 | NR1H2 (0.44) | NPC1NR1H2NR1H3KDM4EALDH1A1 | |
| SCHEMBL6609250 | 0.83 | CHEK2 (0.56) | NPC1CHEK2KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL4860072 | 0.82 | PARP1 (0.58) | TEAD1TEAD3NPC1NR1H2NR1H3 | |
| SCHEMBL13340759 | 0.82 | PARP1 (0.58) | TEAD1TEAD3NPC1NR1H2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007094513-A2 | CYCLIC AMINE COMPOUND AND USE THEREOF FOR THE PROPHYLAXIS OR TREATMENT OF HYPERTENSION | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-08-23 | — | — | WO | disclosed |