Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 6/20 | 0.51 |
| ▸ | GSK3B | P49841 | 10/20 | 0.46 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.44 |
| ▸ | CDK1 | P06493 | 2/20 | 0.44 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.44 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.44 |
| ▸ | CDK2 | P24941 | 8/20 | 0.44 |
| ▸ | CDK4 | P11802 | 6/20 | 0.44 |
| ▸ | TTK | P33981 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 2/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.39 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8233943 | 0.78 | CDK4 (0.54) | DYRK1AGSK3BCDK1CCNB1CDK2 | |
| SCHEMBL8233833 | 0.76 | DYRK1A (0.56) | DYRK1AGSK3BCDK2CDK4TTK | |
| SCHEMBL14676415 | 0.76 | PLAU (0.48) | CCNB2CDK1CCNB1CCNB3MAPK8 | |
| SCHEMBL8237980 | 0.71 | CDK2 (0.46) | DYRK1AGSK3BCDK2CDK4 | |
| SCHEMBL8233534 | 0.71 | CXCR4 (0.44) | DYRK1AGSK3BCDK2CDK4MKNK1 | |
| SCHEMBL31691135 | 0.71 | EGFR (0.50) | DYRK1ACCNB2CDK1CCNB1CCNB3 | |
| SCHEMBL26644381 | 0.71 | EGFR (0.50) | DYRK1ACCNB2CDK1CCNB1CCNB3 | |
| SCHEMBL8229268 | 0.70 | GSK3B (0.47) | DYRK1AGSK3BCCNB2CDK1CCNB1 | |
| SCHEMBL8228313 | 0.70 | DYRK1A (0.54) | DYRK1AGSK3BCDK2CDK4 | |
| SCHEMBL8235923 | 0.70 | MKNK1 (0.43) | DYRK1AGSK3BCDK2CDK4MKNK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007129195-A2 | 4-PYRIMIDINE-5-AMINO-PYRAZOLE COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2007-11-15 | — | — | WO | disclosed |