Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | SOAT1 | P35610 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 7/20 | 0.35 |
| ▸ | CA2 | P00918 | 7/20 | 0.35 |
| ▸ | CA4 | P22748 | 7/20 | 0.35 |
| ▸ | CA9 | Q16790 | 7/20 | 0.35 |
| ▸ | CETP | P11597 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3495109 | 0.91 | TSHR (0.41) | TSHRLMNAPLA2G1BKMT2ANPSR1 | |
| SCHEMBL3492306 | 0.88 | TSHR (0.44) | TSHRLMNAPLA2G1BKMT2ANPSR1 | |
| SCHEMBL13340197 | 0.86 | HDAC1 (0.41) | TSHRLMNAPLA2G1BKMT2ANPSR1 | |
| SCHEMBL3493260 | 0.86 | TSHR (0.45) | TSHRLMNAPLA2G1BKMT2ANPSR1 | |
| SCHEMBL8237483 | 0.84 | TSHR (0.42) | TSHRLMNAPLA2G1BKMT2ANPSR1 | |
| SCHEMBL3493927 | 0.83 | CA1 (0.39) | TSHRLMNAPLA2G1BKMT2ANPSR1 | |
| SCHEMBL3494534 | 0.82 | CA1 (0.36) | TSHRLMNAPLA2G1BKMT2ANPSR1 | |
| SCHEMBL8231116 | 0.81 | TSHR (0.43) | TSHRALDH1A1CA1CA2CA4 | |
| SCHEMBL3493714 | 0.80 | HDAC1 (0.41) | TSHRLMNAPLA2G1BKMT2ANPSR1 | |
| SCHEMBL3492703 | 0.80 | CA1 (0.40) | TSHRKMT2ASMN1; SMN2ALDH1A1CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007094513-A2 | CYCLIC AMINE COMPOUND AND USE THEREOF FOR THE PROPHYLAXIS OR TREATMENT OF HYPERTENSION | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-08-23 | — | — | WO | disclosed |