Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 8/20 | 0.55 |
| ▸ | BACE2 | Q9Y5Z0 | 8/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | MGLL | Q99685 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | UBE2M | P61081 | 1/20 | 0.36 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | APP | P05067 | 1/20 | 0.35 |
| ▸ | CTSD | P07339 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8228815 | 0.94 | BACE1 (0.55) | BACE1BACE2L3MBTL1GAAMGLL | |
| SCHEMBL8234677 | 0.94 | BACE1 (0.55) | BACE1BACE2L3MBTL1GAAMGLL | |
| SCHEMBL5146664 | 0.87 | BACE1 (0.74) | BACE1BACE2GAAAPPCTSD | |
| SCHEMBL14422949 | 0.81 | BACE1 (0.74) | BACE1BACE2GAAAPPCTSD | |
| SCHEMBL5147714 | 0.81 | BACE1 (0.74) | BACE1BACE2GAAAPPCTSD | |
| SCHEMBL4759401 | 0.80 | BACE1 (0.76) | BACE1BACE2APPCTSD | |
| SCHEMBL5146668 | 0.80 | BACE1 (0.73) | BACE1BACE2GAAAPPCTSD | |
| SCHEMBL5146654 | 0.79 | BACE1 (0.72) | BACE1BACE2APPCTSD | |
| SCHEMBL5167106 | 0.76 | BACE1 (0.66) | BACE1BACE2L3MBTL1GAAALDH1A1 | |
| SCHEMBL4707008 | 0.71 | BACE1 (0.84) | BACE1BACE2APPCTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007078813-A2 | 2-AMINO-5-PIPERIDINYLIMIDAZOLONE COMPOUNDS AND USE THEREOF FOR β-SECRETASE MODULATION | WYETH (US) | 2007-07-12 | — | — | WO | disclosed |