Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 19/20 | 0.46 |
| ▸ | BACE2 | Q9Y5Z0 | 3/20 | 0.44 |
| ▸ | CTSD | P07339 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4532280 | 0.83 | BACE1 (0.65) | BACE1BACE2CTSD | |
| SCHEMBL4517342 | 0.81 | BACE1 (0.60) | BACE1BACE2CTSD | |
| SCHEMBL4517698 | 0.80 | BACE1 (0.62) | BACE1BACE2CTSD | |
| SCHEMBL4522756 | 0.80 | BACE1 (0.52) | BACE1BACE2CTSD | |
| SCHEMBL4529144 | 0.79 | BACE1 (0.66) | BACE1BACE2CTSD | |
| SCHEMBL4525764 | 0.78 | BACE1 (0.49) | BACE1BACE2CTSD | |
| SCHEMBL4535412 | 0.78 | BACE1 (0.64) | BACE1BACE2CTSD | |
| SCHEMBL8231872 | 0.72 | BACE1 (0.45) | BACE1BACE2CTSD | |
| SCHEMBL8241158 | 0.71 | BACE1 (0.43) | BACE1BACE2CTSD | |
| SCHEMBL8238548 | 0.71 | BACE1 (0.43) | BACE1BACE2CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007058602-A2 | NOVEL 2-AMINO-IMIDAZOLE-4-ONE COMPOUNDS AND THEIR USE IN THE MANUFACTURE OF A MEDICAMENT TO BE USED IN THE TREATMENT OF COGNITIVE IMPAIRMENT, ALZHEIMER’S DISEASE, NEURODEGENERATION AND DEMENTIA. | ASTRAZENECA AB (SE) | 2007-05-24 | — | — | WO | disclosed |