SCHEMBL8240366

SCHEMBL8240366

CC(=O)NC(Cc1cc(F)cc(F)c1)C(O)CNC1(c2cccc(N3CCCCC3)c2)CC1

nearest known ligand 0.82

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
BACE1 P56817 20/20 0.82
CTSD P07339 5/20 0.72

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4699990 0.92 BACE1 (0.94) BACE1CTSD
SCHEMBL4699820 0.92 BACE1 (0.88) BACE1CTSD
SCHEMBL4701705 0.92 BACE1 (0.73) BACE1CTSD
SCHEMBL8243489 0.88 BACE1 (0.78) BACE1CTSD
SCHEMBL6041020 0.86 BACE1 (1.00) BACE1CTSD
SCHEMBL5667125 0.86 BACE1 (0.85) BACE1CTSD
SCHEMBL13349523 0.85 BACE1 (0.78) BACE1CTSD
SCHEMBL5579147 0.84 BACE1 (0.77) BACE1CTSD
SCHEMBL5579143 0.84 BACE1 (0.77) BACE1CTSD
SCHEMBL5668498 0.84 BACE1 (1.00) BACE1CTSD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2007047306-A1 METHODS OF TREATING AMYLOIDOSIS USING ARYL-CYCLOPROPYL DERIVATIVE ASPARTYL PROTEASE INHIBITORS ELAN PHARMACEUTICALS, INC. (US) 2007-04-26 WO disclosed