Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTCH1 | P46531 | 4/20 | 0.49 |
| ▸ | RBPJ | Q06330 | 3/20 | 0.49 |
| ▸ | MMP2 | P08253 | 13/20 | 0.44 |
| ▸ | MMP3 | P08254 | 13/20 | 0.44 |
| ▸ | MMP7 | P09237 | 12/20 | 0.44 |
| ▸ | MMP1 | P03956 | 10/20 | 0.43 |
| ▸ | MMP8 | P22894 | 2/20 | 0.43 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.43 |
| ▸ | MMP9 | P14780 | 1/20 | 0.43 |
| ▸ | MMP12 | P39900 | 1/20 | 0.43 |
| ▸ | MMP13 | P45452 | 1/20 | 0.43 |
| ▸ | MMP14 | P50281 | 1/20 | 0.43 |
| ▸ | PSEN1 | P49768 | 4/20 | 0.43 |
| ▸ | PSEN2 | P49810 | 4/20 | 0.43 |
| ▸ | APH1B | Q8WW43 | 4/20 | 0.43 |
| ▸ | NCSTN | Q92542 | 4/20 | 0.43 |
| ▸ | APH1A | Q96BI3 | 4/20 | 0.43 |
| ▸ | PSENEN | Q9NZ42 | 4/20 | 0.43 |
| ▸ | NOTCH3 | Q9UM47 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8241343 | 0.91 | NOTCH1 (0.53) | NOTCH1RBPJMMP2MMP3MMP7 | |
| SCHEMBL13325960 | 0.90 | NOTCH1 (0.47) | NOTCH1RBPJMMP2MMP3MMP7 | |
| SCHEMBL3289472 | 0.89 | NOTCH1 (0.61) | NOTCH1RBPJMMP2MMP3MMP7 | |
| SCHEMBL8244299 | 0.82 | PSEN1 (0.57) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8241822 | 0.81 | PSEN1 (0.54) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL3286164 | 0.79 | PSEN1 (0.64) | NOTCH1RBPJPSEN1PSEN2APH1B | |
| SCHEMBL4108341 | 0.79 | PSEN1 (0.64) | NOTCH1RBPJPSEN1PSEN2APH1B | |
| SCHEMBL6005977 | 0.75 | NOTCH1 (0.72) | NOTCH1RBPJPSEN1PSEN2APH1B | |
| SCHEMBL13325780 | 0.74 | NOTCH1 (0.66) | NOTCH1RBPJPSEN1PSEN2APH1B | |
| SCHEMBL3287904 | 0.73 | NOTCH1 (0.53) | NOTCH1RBPJPSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060122169-A1 | Succinoylamino benzodiazepines as inhibitors of Abeta protein production | DUPONT PHARMACEUTICALS (US) | 2006-06-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060122169-A1 | Succinoylamino benzodiazepines as inhibitors of Abeta protein production | BACE1, APP, GABRE | NOTCH1 539/4885RBPJ 2293/4885MMP2 3672/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.