Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 4/20 | 0.58 |
| ▸ | PLG | P00747 | 3/20 | 0.58 |
| ▸ | PPARG | P37231 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3192269 | 0.89 | PPARG (0.54) | PLAUPLGPPARGHDAC8HDAC6 | |
| SCHEMBL13299388 | 0.88 | PPARG (0.56) | PLAUPLGPPARGHDAC8HDAC6 | |
| SCHEMBL28882432 | 0.86 | HDAC6 (0.64) | PLAUPLGPPARGHDAC8HDAC6 | |
| SCHEMBL3184013 | 0.85 | PPARG (0.55) | PLAUPLGPPARGHDAC8HDAC6 | |
| SCHEMBL6085876 | 0.83 | IDO1 (0.50) | PLAUPLGPPARGLMNAHDAC8 | |
| SCHEMBL13299386 | 0.83 | KCNJ1 (0.53) | PLAUPLGPPARGHDAC8HDAC6 | |
| SCHEMBL23902646 | 0.82 | NPC1 (0.49) | PLAUPLGPPARGNPC1HSP90AA1 | |
| SCHEMBL2770283 | 0.82 | HDAC3 (0.51) | PLAUPLGPPARGHDAC8HDAC6 | |
| SCHEMBL20740753 | 0.82 | NPC1 (0.49) | PLAUPLGPPARGNPC1HSP90AA1 | |
| SCHEMBL30534841 | 0.82 | NPC1 (0.49) | PLAUPLGPPARGNPC1HSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007022321-A2 | SUBSTITUTED INDOLES AND USE THEREOF | WYETH (US) | 2007-02-22 | — | — | WO | disclosed |