Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 20/20 | 0.81 |
| ▸ | PDE6A | P16499 | 12/20 | 0.81 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8244520 | 0.91 | PDE5A (0.77) | PDE5APDE6APDE11A | |
| SCHEMBL8244544 | 0.91 | PDE5A (0.77) | PDE5APDE6APDE11A | |
| SCHEMBL8250195 | 0.91 | PDE5A (0.72) | PDE5APDE6APDE11A | |
| SCHEMBL8244274 | 0.90 | PDE5A (1.00) | PDE5APDE6APDE11A | |
| SCHEMBL8244033 | 0.85 | PDE5A (0.91) | PDE5APDE6APDE11A | |
| SCHEMBL8253382 | 0.84 | PDE5A (0.70) | PDE5APDE6APDE11A | |
| SCHEMBL8255134 | 0.84 | PDE5A (0.69) | PDE5APDE6APDE11A | |
| SCHEMBL8243988 | 0.83 | PDE5A (0.73) | PDE5APDE6APDE11A | |
| SCHEMBL8251453 | 0.83 | PDE5A (0.75) | PDE5APDE6APDE11A | |
| SCHEMBL6073255 | 0.82 | PDE5A (0.74) | PDE5APDE6APDE11A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006126081-A2 | PYRIDINO [2 , 3-B] PYRAZINONES AS PDE-5 INHIBITORS | PHARMACIA & UPJOHN COMPANY LLC (US) | 2006-11-30 | — | — | WO | disclosed |