Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE7A | Q13946 | 20/20 | 0.53 |
| ▸ | PDE7B | Q9NP56 | 3/20 | 0.53 |
| ▸ | PDE4D | Q08499 | 14/20 | 0.52 |
| ▸ | PDE1A | P54750 | 10/20 | 0.52 |
| ▸ | PDE1B | Q01064 | 10/20 | 0.52 |
| ▸ | PDE1C | Q14123 | 10/20 | 0.52 |
| ▸ | PDE5A | O76074 | 5/20 | 0.48 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13899377 | 0.99 | PDE7A (0.55) | PDE7APDE7BPDE4DPDE1APDE1B | |
| SCHEMBL3951908 | 0.91 | PDE7A (0.56) | PDE7APDE7BPDE4DPDE1APDE1B | |
| SCHEMBL3950069 | 0.90 | PDE7A (0.58) | PDE7APDE7BPDE4DPDE1APDE1B | |
| SCHEMBL3950067 | 0.90 | PDE7A (0.58) | PDE7APDE7BPDE4DPDE1APDE1B | |
| SCHEMBL3958085 | 0.86 | PDE7A (0.58) | PDE7APDE7BPDE4DPDE1APDE1B | |
| SCHEMBL3960099 | 0.83 | PDE7A (0.59) | PDE7APDE7BPDE4DPDE1APDE1B | |
| SCHEMBL13899460 | 0.83 | PDE7A (0.62) | PDE7APDE7BPDE4DPDE1APDE1B | |
| SCHEMBL298595 | 0.83 | PDE7A (0.62) | PDE7APDE7BPDE4DPDE1APDE1B | |
| SCHEMBL3951868 | 0.82 | PDE7A (0.64) | PDE7APDE7BPDE4DPDE1APDE1B | |
| SCHEMBL3949230 | 0.82 | PDE7A (0.64) | PDE7APDE7BPDE4DPDE1APDE1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007063391-A2 | SPIROCYCLIC QUINAZOLINE DERIVATIVES AS PDE7 INHIBITORS | PFIZER LIMITED (GB) | 2007-06-07 | — | — | WO | disclosed |