Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 5/20 | 0.50 |
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 3/20 | 0.38 |
| ▸ | CSF1R | P07333 | 1/20 | 0.37 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14007382 | 0.86 | PDE4B (0.55) | PDE4BPDE4APDE4CPDE4DSYK | |
| SCHEMBL4607339 | 0.85 | PDE4B (0.53) | PDE4BPDE4APDE4CPDE4DSYK | |
| SCHEMBL4607911 | 0.83 | PDE4B (0.51) | PDE4BPDE4APDE4CPDE4DSYK | |
| SCHEMBL4606748 | 0.82 | PDE4B (0.73) | PDE4BPDE4APDE4CPDE4DSYK | |
| SCHEMBL8259959 | 0.78 | PDE4B (0.71) | PDE4BPDE4APDE4CPDE4DSYK | |
| SCHEMBL14007383 | 0.73 | PDE4B (0.45) | PDE4BPDE4APDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL4606041 | 0.72 | PDE4B (0.72) | PDE4BCSF1RLRRK2 | |
| SCHEMBL4930884 | 0.72 | PDE4B (0.51) | PDE4BPDE4APDE4CPDE4DSYK | |
| SCHEMBL4608045 | 0.69 | PDE4B (0.57) | PDE4BCSF1RLRRK2 | |
| SCHEMBL8258162 | 0.68 | PDE4B (0.51) | PDE4BPDE4APDE4CPDE4DSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007045861-A1 | CINNOLINE COMPOUNDS AS INHIBITORS OF PHOSPHODIESTERASE TYPE IV (PDE4) | GLAXO GROUP LIMITED (GB) | 2007-04-26 | — | — | WO | disclosed |