Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 5/20 | 0.48 |
| ▸ | PARP2 | Q9UGN5 | 3/20 | 0.48 |
| ▸ | ATM | Q13315 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | CCR3 | P51677 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1001863 | 0.91 | ATM (0.53) | PARP1PARP2ATMHTR1AMEN1 | |
| SCHEMBL1001867 | 0.89 | MEN1 (0.46) | PARP1PARP2MEN1KMT2A | |
| SCHEMBL1002130 | 0.83 | PARP1 (0.50) | PARP1PARP2HTR1ACCR3 | |
| SCHEMBL1003044 | 0.83 | PARP1 (0.53) | PARP1PARP2ATMALDH1A1SIGMAR1 | |
| SCHEMBL1001898 | 0.82 | PARP1 (0.49) | PARP1PARP2MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL1000989 | 0.81 | PARP1 (0.51) | PARP1PARP2ALDH1A1HTR1ASIGMAR1 | |
| SCHEMBL1005063 | 0.79 | PARP1 (0.48) | PARP1PARP2HTR1ACCR3 | |
| SCHEMBL1002269 | 0.79 | PARP1 (0.43) | PARP1PARP2SMN1; SMN2 | |
| SCHEMBL1003204 | 0.79 | PARP1 (0.51) | PARP1PARP2ALDH1A1SIGMAR1SMN1; SMN2 | |
| SCHEMBL1002883 | 0.77 | PARP1 (0.47) | PARP1PARP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007021309-A1 | SUBSTITUTED ISOINDOLONES AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR POTENTIATORS | ASTRAZENECA AB (SE) | 2007-02-22 | — | — | WO | disclosed |