SCHEMBL8247126

SCHEMBL8247126

C[C@@H](C(=O)NCc1ccc(NC#N)cc1)N(C)C(=O)[C@@H](CO)NS(=O)(=O)Cc1ccc(Cl)cc1

nearest known ligand 0.36

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ CNR1 P21554 3/20 0.36
▸ CNR2 P34972 1/20 0.36
▸ LSS P48449 1/20 0.36
▸ F2 P00734 2/20 0.35
▸ F10 P00742 2/20 0.35
▸ CA12 O43570 1/20 0.34
▸ CA1 P00915 1/20 0.34
▸ CA2 P00918 1/20 0.34
▸ CA7 P43166 1/20 0.34
▸ AVPR1A P37288 1/20 0.34
▸ NPC1 O15118 1/20 0.33
▸ RAB9A P51151 1/20 0.33
▸ ALDH1A1 P00352 1/20 0.33
▸ LMNA P02545 1/20 0.33
▸ POLB P06746 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13621598 0.86 F2 (0.39) F2F10CA1CA2CA7
SCHEMBL13621597 0.85 LSS (0.39) LSSF2F10CA12CA1
SCHEMBL8247131 0.85 LSS (0.39) LSSF2F10CA12CA1
SCHEMBL5498879 0.85 LSS (0.39) LSSF2F10CA12CA1
SCHEMBL13621604 0.80 LSS (0.36) LSSF2F10CA12CA1
SCHEMBL13621609 0.80 LSS (0.36) LSSF2F10CA12CA1
SCHEMBL13632161 0.80 LSS (0.35) LSSF2F10CA12CA1
SCHEMBL13632157 0.80 LSS (0.35) LSSF2F10CA12CA1
SCHEMBL13621595 0.80 LSS (0.35) LSSF2F10CA12CA1
SCHEMBL13621603 0.76 EPHX2 (0.40) LSSCA12ALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090286837-A1 Oxadiazole compounds as urokinase inhibitors WILEX AG (DE) 2009-11-19 — — US disclosed
US-20090286837-A1 Oxadiazole compounds as urokinase inhibitors WILEX AG (DE) 2009-11-19 — — US disclosed
WO-2007025718-A1 OXADIAZOLE COMPOUNDS AS UROKINASE INHIBITORS WILEX AG (DE) 2007-03-08 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090286837-A1 Oxadiazole compounds as urokinase inhibitors PLAUR, PLAU, PLAT CNR1 2760/4885CNR2 2890/4885LSS 3492/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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