Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 5/20 | 0.72 |
| ▸ | MDM2 | Q00987 | 4/20 | 0.72 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | CCR2 | P41597 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8249405 | 0.95 | TP53 (0.77) | TP53MDM2FAAHMAPTSMN1; SMN2 | |
| SCHEMBL8251713 | 0.93 | MDM2 (0.79) | TP53MDM2FAAHMAPTSMN1; SMN2 | |
| SCHEMBL4966825 | 0.93 | TP53 (0.73) | TP53MDM2FAAHMAPTSMN1; SMN2 | |
| SCHEMBL3964722 | 0.93 | TP53 (0.76) | TP53MDM2FAAHMAPTSMN1; SMN2 | |
| SCHEMBL8251323 | 0.92 | MDM2 (0.70) | TP53MDM2FAAHMAPTSMN1; SMN2 | |
| SCHEMBL8247285 | 0.92 | MDM2 (0.72) | TP53MDM2FAAHMAPTLMNA | |
| SCHEMBL8249668 | 0.92 | MDM2 (0.77) | TP53MDM2FAAHMAPTSMN1; SMN2 | |
| SCHEMBL3971734 | 0.92 | MDM2 (0.71) | TP53MDM2FAAHMAPTSMN1; SMN2 | |
| SCHEMBL8252352 | 0.91 | MDM2 (0.75) | TP53MDM2FAAHMAPTSMN1; SMN2 | |
| SCHEMBL3964399 | 0.91 | TP53 (0.72) | TP53MDM2FAAHMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7576082-B2 | Oxindole derivatives | HOFFMAN-LA ROCHE INC. (US) | 2009-08-18 | — | — | US | disclosed |
| US-7576082-B2 | Oxindole derivatives | HOFFMAN-LA ROCHE INC. (US) | 2009-08-18 | — | — | US | disclosed |
| WO-2006136606-A2 | OXINDOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2006-12-28 | — | — | WO | disclosed |