Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.63 |
| ▸ | NPC1 | O15118 | 2/20 | 0.63 |
| ▸ | RAB9A | P51151 | 2/20 | 0.63 |
| ▸ | POLB | P06746 | 1/20 | 0.63 |
| ▸ | BLM | P54132 | 1/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | HTT | P42858 | 3/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | MPC2 | O95563 | 1/20 | 0.50 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | PPARG | P37231 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29207051 | 0.86 | NPC1 (0.81) | SMN1; SMN2NPC1RAB9APOLBBLM | |
| SCHEMBL12916784 | 0.82 | NPC1 (0.63) | SMN1; SMN2NPC1RAB9APOLBBLM | |
| SCHEMBL6181838 | 0.81 | NPC1 (0.73) | SMN1; SMN2NPC1RAB9APOLBBLM | |
| SCHEMBL29207027 | 0.80 | NPC1 (0.76) | SMN1; SMN2NPC1RAB9APOLBBLM | |
| SCHEMBL19828398 | 0.79 | SMN1; SMN2 (0.75) | SMN1; SMN2NPC1RAB9APOLBBLM | |
| SCHEMBL21100591 | 0.79 | MAPT (0.73) | SMN1; SMN2NPC1RAB9APOLBBLM | |
| SCHEMBL15179057 | 0.78 | NPC1 (0.78) | SMN1; SMN2NPC1RAB9APOLBBLM | |
| SCHEMBL1416886 | 0.78 | NPC1 (0.73) | SMN1; SMN2NPC1RAB9APOLBBLM | |
| SCHEMBL6321080 | 0.78 | NPC1 (0.73) | SMN1; SMN2NPC1RAB9APOLBBLM | |
| SCHEMBL2564933 | 0.77 | NPC1 (0.71) | SMN1; SMN2NPC1RAB9APOLBBLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006138264-A2 | ASPARTYL PROTEASE INHIBITORS | SCHERING CORPORATION (US) | 2006-12-28 | — | — | WO | disclosed |