Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 20/20 | 0.81 |
| ▸ | PDE6A | P16499 | 19/20 | 0.81 |
| ▸ | PDE11A | Q9HCR9 | 2/20 | 0.81 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.78 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.78 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8241881 | 0.96 | PDE5A (0.77) | PDE5APDE6APDE11APDE4BPDE4D | |
| SCHEMBL5811217 | 0.92 | PDE5A (0.77) | PDE5APDE6APDE11APDE4BPDE4D | |
| SCHEMBL8242727 | 0.91 | PDE5A (0.83) | PDE5APDE6APDE11APDE4BPDE4D | |
| SCHEMBL8247867 | 0.91 | PDE5A (0.86) | PDE5APDE6APDE11AKCNH2 | |
| SCHEMBL5808570 | 0.90 | PDE5A (1.00) | PDE5APDE6APDE11AKCNH2 | |
| SCHEMBL5812205 | 0.88 | PDE5A (1.00) | PDE5APDE6APDE11APDE4BPDE4D | |
| SCHEMBL8250250 | 0.88 | PDE5A (1.00) | PDE5APDE6APDE11APDE4BPDE4D | |
| SCHEMBL5814292 | 0.87 | PDE5A (1.00) | PDE5APDE6APDE11AKCNH2 | |
| SCHEMBL8251106 | 0.86 | PDE5A (0.78) | PDE5APDE6APDE11AKCNH2 | |
| SCHEMBL8247881 | 0.86 | PDE5A (0.71) | PDE5APDE6APDE11APDE4BPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006126082-A2 | PYRIDINE [3,4-B] PYRAZINONES AS PDE-5 INHIBITORS | PHARMACIA & UPJOHN COMPANY LLC (US) | 2006-11-30 | — | — | WO | disclosed |