Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR1A | P37288 | 8/20 | 0.46 |
| ▸ | CNR1 | P21554 | 2/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.38 |
| ▸ | TACR3 | P29371 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8251835 | 0.86 | AVPR1A (0.48) | AVPR1ACNR1MEN1KMT2AADRA1D | |
| SCHEMBL4361153 | 0.82 | AVPR1A (0.57) | AVPR1ACNR1CNR2MEN1KMT2A | |
| SCHEMBL8241424 | 0.81 | AVPR1A (0.69) | AVPR1ACNR1ALDH1A1 | |
| SCHEMBL4359158 | 0.81 | AVPR1A (0.69) | AVPR1ACNR1CNR2MEN1KMT2A | |
| SCHEMBL4359118 | 0.81 | AVPR1A (0.55) | AVPR1ACNR1CNR2MEN1KMT2A | |
| SCHEMBL8251337 | 0.79 | AVPR1A (0.51) | AVPR1ACNR1ALDH1A1 | |
| SCHEMBL8249649 | 0.78 | AVPR1A (0.50) | AVPR1ACNR1ALDH1A1 | |
| SCHEMBL13971309 | 0.77 | AVPR1A (0.44) | AVPR1ACNR1KMT2AALDH1A1 | |
| SCHEMBL14580413 | 0.76 | AVPR1A (0.46) | AVPR1ACNR1CNR2MEN1KMT2A | |
| SCHEMBL613261 | 0.74 | CNR1 (0.43) | CNR1CNR2MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007006688-A1 | INDOL-3-CARBONYL-SPIRO-PIPERIDINE DERIVATIVES AS V1A RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-01-18 | — | — | WO | disclosed |