Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 7/20 | 0.70 |
| ▸ | EGLN3 | Q9H6Z9 | 3/20 | 0.57 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.55 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8247279 | 0.87 | EGLN1 (0.72) | EGLN1EGLN3EGLN2HTTHIF1A | |
| SCHEMBL8238446 | 0.87 | EGLN1 (0.72) | EGLN1EGLN3EGLN2HTTHIF1A | |
| SCHEMBL8248294 | 0.86 | EGLN1 (0.77) | EGLN1EGLN3EGLN2HIF1AKDM4E | |
| SCHEMBL8238459 | 0.86 | EGLN1 (0.67) | EGLN1EGLN3EGLN2HTTLMNA | |
| SCHEMBL8247257 | 0.85 | EGLN1 (0.60) | EGLN1EGLN3EGLN2HTTLMNA | |
| SCHEMBL5305960 | 0.84 | EGLN1 (0.74) | EGLN1EGLN3EGLN2HIF1AMEN1 | |
| SCHEMBL5307125 | 0.84 | EGLN1 (0.61) | EGLN1EGLN3EGLN2HTTLMNA | |
| SCHEMBL8244773 | 0.83 | EGLN1 (0.76) | EGLN1EGLN3EGLN2HTTLMNA | |
| SCHEMBL8244770 | 0.83 | EGLN1 (0.79) | EGLN1EGLN3EGLN2HIF1AMEN1 | |
| SCHEMBL8244419 | 0.82 | EGLN1 (1.00) | EGLN1EGLN3EGLN2HTTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007038571-A2 | PROLYL HYDROXYLASE ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-04-05 | — | — | WO | disclosed |