Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | LSS | P48449 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 2/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.36 |
| ▸ | PRCP | P42785 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | GPR6 | P46095 | 1/20 | 0.35 |
| ▸ | TNF | P01375 | 1/20 | 0.35 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.35 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12413538 | 0.91 | GRM2 (0.47) | ALDH1A1GRM2TSHRLSSKCNH2 | |
| SCHEMBL2022539 | 0.87 | GRM2 (0.44) | ALDH1A1GRM2TSHRCHRM5HCRTR1 | |
| SCHEMBL2024727 | 0.84 | GRM2 (0.44) | ALDH1A1GRM2TSHRDRD4GPR6 | |
| SCHEMBL12580818 | 0.83 | GPR6 (0.46) | ALDH1A1GRM2TSHRKCNH2GPR6 | |
| SCHEMBL2026888 | 0.82 | GRM2 (0.47) | ALDH1A1GRM2TSHRCHRM5HCRTR1 | |
| SCHEMBL1001844 | 0.82 | GRM2 (0.43) | ALDH1A1GRM2TSHRBCHEACHE | |
| SCHEMBL1001587 | 0.82 | GRM2 (0.42) | ALDH1A1GRM2TSHRKCNH2CHRM5 | |
| SCHEMBL2022149 | 0.81 | HTT (0.48) | ALDH1A1GRM2TSHRDRD4DRD2 | |
| SCHEMBL8246819 | 0.81 | GRM2 (0.45) | ALDH1A1GRM2TSHRCHRM5HCRTR1 | |
| SCHEMBL2026639 | 0.81 | GRM2 (0.47) | ALDH1A1GRM2TSHRCHRM5HCRTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007021309-A1 | SUBSTITUTED ISOINDOLONES AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR POTENTIATORS | ASTRAZENECA AB (SE) | 2007-02-22 | — | — | WO | disclosed |