Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 12/20 | 0.49 |
| ▸ | PDE3B | Q13370 | 4/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.32 |
| ▸ | PDE1A | P54750 | 2/20 | 0.32 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.31 |
| ▸ | PDE2A | O00408 | 1/20 | 0.30 |
| ▸ | PDE8A | O60658 | 1/20 | 0.30 |
| ▸ | PDE5A | O76074 | 1/20 | 0.30 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.30 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.30 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18745385 | 0.75 | PDE4A (0.73) | PDE4APDE3BP2RX7PDE2APDE8A | |
| SCHEMBL15255681 | 0.59 | PDE4A (0.48) | PDE4APDE3BPDE3APDE1APDE1B | |
| SCHEMBL18745358 | 0.56 | PDE4A (0.54) | PDE4APDE3BPDE2APDE8APDE5A | |
| SCHEMBL4919936 | 0.56 | PDE1A (0.56) | PDE4APDE3BPDE1APDE1BPDE2A | |
| SCHEMBL4921416 | 0.55 | PDE4A (1.00) | PDE4APDE3BPDE2APDE8APDE5A | |
| SCHEMBL232826 | 0.55 | PDE5A (0.59) | PDE4APDE3BPDE3AP2RX7PDE5A | |
| SCHEMBL12198172 | 0.55 | PDE4A (0.68) | PDE4APDE3BPDE2APDE8APDE5A | |
| SCHEMBL8060117 | 0.54 | PDE4A (1.00) | PDE4APDE3BPDE2APDE8APDE5A | |
| SCHEMBL10201625 | 0.54 | PDE5A (0.78) | PDE4APDE3BPDE3AP2RX7PDE5A | |
| SCHEMBL20462771 | 0.54 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006133261-A2 | ORGANIC COMPOUNDS | INTRA-CELLULAR THERAPIES, INC. (US) | 2006-12-14 | — | — | WO | disclosed |