Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | F10 | P00742 | 16/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8259083 | 0.82 | MAPK1 (0.47) | MAPK1F10HPGDTSHR | |
| SCHEMBL3309272 | 0.81 | F10 (0.51) | MAPK1F10TSHRF2 | |
| SCHEMBL3309265 | 0.81 | F10 (0.51) | MAPK1F10TSHRF2 | |
| SCHEMBL13436103 | 0.80 | F10 (0.46) | MAPK1F10HPGDTSHR | |
| SCHEMBL3552201 | 0.80 | F10 (0.46) | MAPK1F10HPGDTSHR | |
| SCHEMBL4591552 | 0.79 | F10 (0.57) | MAPK1F10ABCB11F2ST14 | |
| SCHEMBL4592555 | 0.79 | F10 (0.57) | MAPK1F10ABCB11F2ST14 | |
| SCHEMBL4592835 | 0.75 | F10 (0.53) | F10F2 | |
| SCHEMBL3447783 | 0.75 | F10 (0.53) | F10F2 | |
| SCHEMBL3553795 | 0.74 | F10 (0.45) | MAPK1F10HPGDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7820699-B2 | Cyclic amines | HOFFMANN-LA ROCHE INC. (US) | 2010-10-26 | — | — | US | disclosed |
| US-7820699-B2 | Cyclic amines | HOFFMANN-LA ROCHE INC. (US) | 2010-10-26 | — | — | US | disclosed |
| WO-2006114401-A2 | NOVEL CYCLIC AMINES | F. HOFFMANN-LA ROCHE AG (CH) | 2006-11-02 | — | — | WO | disclosed |