Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL2 | P60568 | 12/20 | 0.56 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.45 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.45 |
| ▸ | ORAI2 | Q96SN7 | 1/20 | 0.45 |
| ▸ | ABL1 | P00519 | 2/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15203529 | 0.96 | IL2 (0.60) | IL2STIM1ORAI1ORAI2ABL1 | |
| SCHEMBL5554312 | 0.85 | IL2 (0.62) | IL2STIM1ORAI1ORAI2ABL1 | |
| SCHEMBL15395925 | 0.82 | IL2 (0.65) | IL2STIM1ORAI1ORAI2ABL1 | |
| SCHEMBL5554285 | 0.82 | IL2 (0.51) | IL2ABL1HDAC4HDAC6MAP4K1 | |
| SCHEMBL15395984 | 0.79 | IL2 (0.59) | IL2STIM1ORAI1ORAI2ABL1 | |
| SCHEMBL15395973 | 0.78 | IL2 (0.61) | IL2STIM1ORAI1ORAI2ABL1 | |
| SCHEMBL5554401 | 0.78 | IL2 (0.61) | IL2STIM1ORAI1ORAI2ABL1 | |
| SCHEMBL5554318 | 0.78 | IL2 (0.60) | IL2STIM1ORAI1ORAI2ABL1 | |
| SCHEMBL5554353 | 0.78 | IL2 (0.60) | IL2STIM1ORAI1ORAI2ABL1 | |
| SCHEMBL8251262 | 0.78 | IL2 (0.51) | IL2STIM1ORAI1ORAI2ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006081391-A2 | COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES | SYNTA PHARMACEUTICALS CORP. (US) | 2006-08-03 | — | — | WO | disclosed |