Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 3/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 11/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.40 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | KIF11 | P52732 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | PDE5A | O76074 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12831416 | 0.89 | HDAC1 (0.58) | HDAC1HDAC6LMNAMEN1KMT2A | |
| SCHEMBL1491499 | 0.88 | HDAC1 (0.48) | HDAC1HDAC6LMNAMEN1KMT2A | |
| SCHEMBL1491400 | 0.88 | HDAC1 (0.48) | HDAC1HDAC6LMNAMEN1KMT2A | |
| SCHEMBL1491403 | 0.88 | HDAC1 (0.48) | HDAC1HDAC6LMNAMEN1KMT2A | |
| SCHEMBL1491496 | 0.88 | HDAC1 (0.48) | HDAC1HDAC6LMNAMEN1KMT2A | |
| SCHEMBL1493521 | 0.79 | HDAC1 (0.47) | HDAC1HDAC6LMNAMEN1KMT2A | |
| SCHEMBL1493520 | 0.79 | HDAC1 (0.47) | HDAC1HDAC6LMNAMEN1KMT2A | |
| SCHEMBL1493519 | 0.79 | HDAC1 (0.47) | HDAC1HDAC6LMNAMEN1KMT2A | |
| SCHEMBL1491340 | 0.79 | TP53 (0.46) | HDAC1LMNATP53MAPTABCG2 | |
| SCHEMBL1491342 | 0.79 | TP53 (0.46) | HDAC1LMNATP53MAPTABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006117549-A1 | ENZYME INHIBITORS | CHROMA THERAPEUTICS LTD (GB) | 2006-11-09 | — | — | WO | disclosed |