Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 19/20 | 0.62 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.53 |
| ▸ | F2 | P00734 | 1/20 | 0.53 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13110326 | 0.88 | F10 (0.62) | F10ABCB11F2ST14PTGS2 | |
| SCHEMBL8257264 | 0.84 | F10 (0.68) | F10ABCB11F2ST14PTGS2 | |
| SCHEMBL3448150 | 0.79 | F10 (0.51) | F10 | |
| SCHEMBL4028227 | 0.78 | F10 (0.82) | F10ABCB11F2ST14PTGS2 | |
| SCHEMBL8260042 | 0.78 | F10 (0.72) | F10 | |
| SCHEMBL13436052 | 0.78 | F10 (0.60) | F10ABCB11F2ST14PTGS2 | |
| SCHEMBL4030183 | 0.77 | F10 (1.00) | F10ABCB11F2ST14PTGS2 | |
| SCHEMBL1999622 | 0.74 | F10 (0.71) | F10ABCB11F2ST14 | |
| SCHEMBL4515461 | 0.74 | F10 (0.64) | F10ABCB11F2ST14PTGS2 | |
| SCHEMBL4490804 | 0.74 | F10 (0.61) | F10ABCB11F2ST14PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7820699-B2 | Cyclic amines | HOFFMANN-LA ROCHE INC. (US) | 2010-10-26 | — | — | US | disclosed |
| US-7820699-B2 | Cyclic amines | HOFFMANN-LA ROCHE INC. (US) | 2010-10-26 | — | — | US | disclosed |
| WO-2006114401-A2 | NOVEL CYCLIC AMINES | F. HOFFMANN-LA ROCHE AG (CH) | 2006-11-02 | — | — | WO | disclosed |