Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL2 | P60568 | 5/20 | 0.45 |
| ▸ | STIM1 | Q13586 | 3/20 | 0.37 |
| ▸ | ORAI1 | Q96D31 | 3/20 | 0.37 |
| ▸ | ORAI2 | Q96SN7 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.34 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.34 |
| ▸ | F10 | P00742 | 3/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TRPC1 | P48995 | 1/20 | 0.32 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8259736 | 0.91 | IL2 (0.38) | IL2STIM1ORAI1ORAI2NPC1 | |
| SCHEMBL8260159 | 0.91 | IL2 (0.55) | IL2STIM1ORAI1ORAI2ABL1 | |
| SCHEMBL8257607 | 0.89 | IL2 (0.42) | IL2STIM1ORAI1ORAI2ABL1 | |
| SCHEMBL8260064 | 0.88 | IL2 (0.46) | IL2STIM1ORAI1ORAI2ABL1 | |
| SCHEMBL8261522 | 0.84 | IL2 (0.37) | IL2STIM1ORAI1ABL1NPC1 | |
| SCHEMBL8258264 | 0.83 | IL2 (0.46) | IL2STIM1ORAI1ORAI2ABL1 | |
| SCHEMBL8260165 | 0.83 | IL2 (0.45) | IL2ABL1 | |
| SCHEMBL8251749 | 0.80 | IL2 (0.53) | IL2STIM1ORAI1ORAI2ABL1 | |
| SCHEMBL15395982 | 0.80 | IL2 (0.55) | IL2STIM1ORAI1ORAI2ABL1 | |
| SCHEMBL8260142 | 0.79 | IL2 (0.56) | IL2STIM1ORAI1ORAI2ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006081391-A2 | COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES | SYNTA PHARMACEUTICALS CORP. (US) | 2006-08-03 | — | — | WO | disclosed |