Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 20/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.69 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.69 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.69 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.65 |
| ▸ | DPP8 | Q6V1X1 | 7/20 | 0.65 |
| ▸ | DPP9 | Q86TI2 | 4/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8257499 | 0.85 | DPP4 (1.00) | DPP4CYP3A4CYP2C19CYP2C9DPP8 | |
| SCHEMBL1407793 | 0.82 | DPP4 (1.00) | DPP4CYP3A4CYP2C19CYP2C9CYP1A2 | |
| SCHEMBL13604978 | 0.80 | DPP4 (1.00) | DPP4CYP3A4CYP2C19CYP2C9DPP8 | |
| SCHEMBL13604976 | 0.79 | DPP4 (1.00) | DPP4CYP3A4CYP2C19CYP2C9DPP8 | |
| SCHEMBL13604975 | 0.79 | DPP4 (1.00) | DPP4CYP3A4CYP2C19CYP2C9DPP8 | |
| SCHEMBL8258920 | 0.79 | DPP4 (1.00) | DPP4CYP3A4CYP2C19CYP2C9CYP1A2 | |
| SCHEMBL8252853 | 0.79 | DPP4 (1.00) | DPP4CYP3A4CYP2C19CYP2C9CYP1A2 | |
| SCHEMBL1407973 | 0.79 | DPP4 (1.00) | DPP4CYP3A4CYP2C19CYP2C9CYP1A2 | |
| SCHEMBL1408016 | 0.76 | DPP4 (1.00) | DPP4DPP8DPP9 | |
| SCHEMBL8252766 | 0.76 | DPP4 (1.00) | DPP4CYP3A4CYP2C19CYP2C9DPP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7635699-B2 | Azolopyrimidine-based inhibitors of dipeptidyl peptidase IV and methods | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-12-22 | — | — | US | disclosed |
| US-7635699-B2 | Azolopyrimidine-based inhibitors of dipeptidyl peptidase IV and methods | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-12-22 | — | — | US | disclosed |
| WO-2006071752-A1 | AZOLOPYRIMIDINE-BASED INHIBITORS OF DIPEPTIDYL PEPTIDASE IV AND METHODS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-07-06 | — | — | WO | disclosed |