Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 20/20 | 1.00 |
| ▸ | DPP7 | Q9UHL4 | 14/20 | 0.86 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.86 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.86 |
| ▸ | DPP9 | Q86TI2 | 5/20 | 0.65 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21067325 | 1.00 | DPP4 (1.00) | DPP4DPP7KCNH2CYP2D6DPP9 | |
| SCHEMBL8260956 | 0.92 | DPP4 (0.86) | DPP4DPP7KCNH2CYP2D6DPP9 | |
| SCHEMBL13342400 | 0.92 | DPP4 (0.86) | DPP4DPP7KCNH2CYP2D6DPP9 | |
| SCHEMBL13342409 | 0.85 | DPP4 (0.87) | DPP4DPP7KCNH2CYP2D6DPP9 | |
| SCHEMBL3535584 | 0.85 | DPP4 (0.87) | DPP4DPP7KCNH2CYP2D6DPP9 | |
| Trifluoroacetic Acid SCHEMBL3537790 | 0.85 | DPP4 (1.00) | DPP4DPP7KCNH2CYP2D6DPP9 | |
| SCHEMBL8261829 | 0.83 | DPP4 (0.71) | DPP4DPP7KCNH2CYP2D6DPP9 | |
| SCHEMBL2469613 | 0.83 | DPP4 (0.71) | DPP4DPP7KCNH2CYP2D6DPP9 | |
| SCHEMBL13342410 | 0.83 | DPP4 (0.71) | DPP4DPP7KCNH2CYP2D6DPP9 | |
| SCHEMBL13342393 | 0.80 | DPP4 (0.82) | DPP4DPP7KCNH2CYP2D6DPP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1819674-B1 | FUSED AMINOPIPERIDINES AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES | MERCK SHARP & DOHME (US) | 2011-10-05 | — | — | EP | disclosed |
| WO-2006058064-A2 | FUSED AMINOPIPERIDINES AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES | MERCK & CO., INC. (US) | 2006-06-01 | — | — | WO | disclosed |