Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 3/20 | 0.72 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.72 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.72 |
| ▸ | DRD3 | P35462 | 3/20 | 0.72 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.72 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.72 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.72 |
| ▸ | CASR | P41180 | 2/20 | 0.72 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.72 |
| ▸ | HTT | P42858 | 2/20 | 0.72 |
| ▸ | MLNR | O43193 | 1/20 | 0.72 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.72 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.72 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.72 |
| ▸ | DRD2 | P14416 | 1/20 | 0.72 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.72 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.72 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.72 |
| ▸ | HRH1 | P35367 | 1/20 | 0.72 |
| ▸ | MC3R | P41968 | 1/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20307882 | 0.90 | CASR (0.74) | HTR2CADRA2CSLC6A4DRD3ADRB1 | |
| SCHEMBL23858339 | 0.85 | CASR (0.73) | HTR2CADRA2CSLC6A4DRD3ADRB1 | |
| SCHEMBL23858316 | 0.85 | CASR (0.73) | HTR2CADRA2CSLC6A4DRD3ADRB1 | |
| Cinacalcet SCHEMBL29360301 | 0.84 | CASR (1.00) | HTR2CADRA2CSLC6A4DRD3ADRB1 | |
| Cinacalcet SCHEMBL30371982 | 0.84 | CASR (1.00) | HTR2CADRA2CSLC6A4DRD3ADRB1 | |
| Cinacalcet SCHEMBL1901469 | 0.84 | CASR (1.00) | HTR2CADRA2CSLC6A4DRD3ADRB1 | |
| Cinacalcet SCHEMBL71876 | 0.84 | CASR (1.00) | HTR2CADRA2CSLC6A4DRD3ADRB1 | |
| Cinacalcet SCHEMBL29373418 | 0.84 | CASR (1.00) | HTR2CADRA2CSLC6A4DRD3ADRB1 | |
| Cinacalcet SCHEMBL3227084 | 0.84 | CASR (1.00) | HTR2CADRA2CSLC6A4DRD3ADRB1 | |
| SCHEMBL13855365 | 0.84 | CASR (0.71) | HTR2CADRA2CSLC6A4DRD3ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006125026-A2 | PROCESS FOR PREPARING CINACALCET HYDROCHLORIDE | TEVA PHARMACEUTICAL INDUSTRIES, LTD. (IL) | 2006-11-23 | — | — | WO | disclosed |