Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.57 |
| ▸ | BRAF | P15056 | 7/20 | 0.54 |
| ▸ | TNNI3K | Q59H18 | 6/20 | 0.54 |
| ▸ | EGFR | P00533 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.49 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.49 |
| ▸ | RAF1 | P04049 | 1/20 | 0.48 |
| ▸ | JAK3 | P52333 | 1/20 | 0.47 |
| ▸ | MELK | Q14680 | 1/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.47 |
| ▸ | KIT | P10721 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7496440 | 0.88 | ABCG2 (0.53) | ABCG2BRAFTNNI3KEGFRJAK3 | |
| SCHEMBL8259230 | 0.86 | BRAF (0.58) | BRAFTNNI3KEGFREIF2AK2GSK3B | |
| SCHEMBL8255837 | 0.84 | CSNK2A2 (0.56) | BRAFTNNI3KEGFRALDH1A1KDM4E | |
| SCHEMBL8255818 | 0.84 | EGFR (0.58) | BRAFTNNI3KEGFRALDH1A1RAF1 | |
| SCHEMBL8256959 | 0.83 | EIF2AK2 (0.62) | BRAFTNNI3KEGFRRAF1EIF2AK2 | |
| SCHEMBL7494933 | 0.81 | EGFR (0.61) | ABCG2BRAFTNNI3KEGFR | |
| SCHEMBL4773624 | 0.81 | EGFR (0.59) | BRAFTNNI3KEGFRKDM4EMEN1 | |
| SCHEMBL8257149 | 0.81 | EGFR (0.54) | BRAFTNNI3KEGFRMAP4K4EIF2AK2 | |
| SCHEMBL5559096 | 0.81 | BRAF (0.53) | BRAFTNNI3KEGFRRAF1EIF2AK2 | |
| SCHEMBL8257175 | 0.80 | EIF2AK2 (0.57) | ABCG2BRAFTNNI3KEGFREIF2AK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7253166-B2 | 6-phenyl-7H-pyrrolo[2,3-d]pyrimidine compounds that induce neuronal differentiation in embryonic stem cells | IRM LLC (BM) | 2007-08-07 | — | — | US | disclosed |
| US-20050038049-A1 | Compounds that induce neuronal differentiation in embryonic stem cells | THE SCRIPPS RESEARCH INSTITUTE (US) | 2005-02-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050038049-A1 | Compounds that induce neuronal differentiation in embryonic stem cells | FER, ERBB3, FLT3 | ABCG2 2110/4885BRAF 57/4885TNNI3K 511/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.