Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 2/20 | 0.62 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.58 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | TMEM97 | Q5BJF2 | 7/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | ABHD6 | Q9BV23 | 2/20 | 0.40 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.40 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20929548 | 0.85 | NR1H2 (0.65) | ESR2NR1H2HDAC1TMEM97SIGMAR1 | |
| SCHEMBL3872052 | 0.83 | ESR2 (0.56) | ESR2NR1H2HDAC1TMEM97SIGMAR1 | |
| SCHEMBL25407569 | 0.81 | ESR2 (0.67) | ESR2NR1H2HDAC1TMEM97SIGMAR1 | |
| SCHEMBL30593262 | 0.81 | ESR2 (0.67) | ESR2NR1H2HDAC1TMEM97SIGMAR1 | |
| SCHEMBL26845053 | 0.79 | ESR2 (0.61) | ESR2NR1H2HDAC1TMEM97SIGMAR1 | |
| SCHEMBL31164748 | 0.79 | ESR2 (0.61) | ESR2NR1H2HDAC1TMEM97SIGMAR1 | |
| SCHEMBL61143 | 0.78 | NR1H2 (0.90) | ESR2NR1H2HDAC1MAPK1NPC1 | |
| SCHEMBL29377835 | 0.78 | NR1H2 (0.90) | ESR2NR1H2HDAC1MAPK1NPC1 | |
| SCHEMBL20929489 | 0.78 | NR1H2 (0.61) | ESR2NR1H2HDAC1TMEM97SIGMAR1 | |
| SCHEMBL4171919 | 0.78 | ESR2 (0.58) | ESR2NR1H2HDAC1TMEM97SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006108709-A1 | 3-SULFONYLAMINO-PYRROLIDINE-2-ONE DERIVATIVES AS FACTOR XA INHIBITORS | GLAXO GROUP LIMITED (GB) | 2006-10-19 | — | — | WO | disclosed |