Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 7/20 | 0.57 |
| ▸ | DDB1 | Q16531 | 6/20 | 0.57 |
| ▸ | TNF | P01375 | 2/20 | 0.46 |
| ▸ | IL1B | P01584 | 2/20 | 0.46 |
| ▸ | IKZF1 | Q13422 | 2/20 | 0.46 |
| ▸ | IKZF3 | Q9UKT9 | 2/20 | 0.46 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.46 |
| ▸ | DPP4 | P27487 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | HSPA1A | P0DMV8 | 1/20 | 0.40 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | TMEM97 | Q5BJF2 | 3/20 | 0.36 |
| ▸ | HTR2B | P41595 | 2/20 | 0.36 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.36 |
| ▸ | HTR3B | O95264 | 1/20 | 0.36 |
| ▸ | HTR3A | P46098 | 1/20 | 0.36 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.36 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL476905 | 0.87 | CRBN (0.74) | CRBNDDB1TNFIL1BIKZF1 | |
| SCHEMBL4674905 | 0.87 | CRBN (0.74) | CRBNDDB1TNFIL1BIKZF1 | |
| SCHEMBL1962200 | 0.87 | CRBN (0.74) | CRBNDDB1TNFIL1BIKZF1 | |
| SCHEMBL30896328 | 0.87 | CRBN (0.74) | CRBNDDB1TNFIL1BIKZF1 | |
| SCHEMBL25876221 | 0.86 | DDB1 (0.54) | CRBNDDB1IKZF3MEN1KMT2A | |
| SCHEMBL13699738 | 0.82 | DDB1 (0.57) | CRBNDDB1TNFIL1BIKZF1 | |
| SCHEMBL7859338 | 0.76 | DDB1 (0.47) | CRBNDDB1TNFIL1BIKZF1 | |
| SCHEMBL6179617 | 0.76 | DDB1 (0.74) | CRBNDDB1TNFIL1BIKZF1 | |
| SCHEMBL2049089 | 0.76 | DDB1 (0.74) | CRBNDDB1TNFIL1BIKZF1 | |
| SCHEMBL2049091 | 0.76 | DDB1 (0.74) | CRBNDDB1TNFIL1BIKZF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006081251-A2 | METHODS AND COMPOSITIONS USING 4-AMINO-2-(3-METHYL-2,6-DIOXOPIPERIDIN-3-YL)-ISOINDOLE-1-3-DIONE | CELGENE CORPORATION (US) | 2006-08-03 | — | — | WO | disclosed |