SCHEMBL8260441

SCHEMBL8260441

CCCCNC(=O)N[C@@H](Cc1ccccc1)C(=O)Nc1ccc2sc(C(=O)NO)cc2c1

nearest known ligand 0.54

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 10/20 0.54
RAB9A P51151 1/20 0.48
TACR2 P21452 6/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5810675 1.00 HDAC1 (0.54) HDAC1RAB9ATACR2
SCHEMBL8260757 0.92 HDAC1 (0.57) HDAC1
SCHEMBL5806429 0.92 HDAC1 (0.57) HDAC1
SCHEMBL8261102 0.90 HDAC1 (0.62) HDAC1
SCHEMBL5823705 0.90 HDAC1 (0.62) HDAC1
SCHEMBL8255855 0.88 HDAC1 (0.61) HDAC1
SCHEMBL5808394 0.88 HDAC1 (0.61) HDAC1TACR2
SCHEMBL5805384 0.88 HDAC1 (0.61) HDAC1
SCHEMBL8255875 0.88 HDAC1 (0.61) HDAC1TACR2
SCHEMBL8258276 0.86 HDAC1 (0.59) HDAC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2006101454-A1 BENZOTHIOPHENE DERIVATIVES: PREPARATION AND PHARMACEUTICAL APPLICATIONS S*BIO PTE LTD (SG) 2006-09-28 WO disclosed