Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 11/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
| ▸ | PDE2A | O00408 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.31 |
| ▸ | CCNK | O75909 | 1/20 | 0.31 |
| ▸ | CCND3 | P30281 | 1/20 | 0.31 |
| ▸ | CDK9 | P50750 | 1/20 | 0.31 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | BTK | Q06187 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8262012 | 0.87 | PDE5A (0.53) | PDE5AKCNH2 | |
| SCHEMBL4476229 | 0.74 | PDE5A (0.61) | PDE5AKCNH2 | |
| SCHEMBL8262521 | 0.72 | ESR1 (0.32) | KDM4EPDE2A | |
| SCHEMBL8261148 | 0.72 | PDE5A (0.70) | PDE5AKCNH2 | |
| SCHEMBL4040756 | 0.72 | PDE5A (0.44) | PDE5ASYKBTK | |
| SCHEMBL4471824 | 0.70 | PDE5A (0.52) | PDE5AKCNH2 | |
| SCHEMBL4040447 | 0.70 | PDE5A (0.41) | PDE5AHPGDCCNKCCND3CDK9 | |
| SCHEMBL4035632 | 0.69 | CCNA2 (0.40) | PDE5ASYKSMN1; SMN2CCNKCCND3 | |
| SCHEMBL8262543 | 0.67 | CCNA2 (0.43) | PDE5AKCNH2 | |
| SCHEMBL27623335 | 0.66 | PDE5A (0.35) | PDE5AKDM4ESYKBTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006046135-A2 | PYRAZOLO[4,3-D] PYRIMIDINE DERIVATIVES USEFUL AS PDE-5 INHIBITORS | PHARMACIA & UPJOHN COMPANY LLC (US) | 2006-05-04 | — | — | WO | disclosed |