Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 19/20 | 0.94 |
| ▸ | BCR | P11274 | 16/20 | 0.94 |
| ▸ | PDGFRA | P16234 | 6/20 | 0.94 |
| ▸ | PDGFRB | P09619 | 5/20 | 0.94 |
| ▸ | SRC | P12931 | 4/20 | 0.94 |
| ▸ | SYK | P43405 | 2/20 | 0.94 |
| ▸ | KIT | P10721 | 8/20 | 0.77 |
| ▸ | ABL2 | P42684 | 5/20 | 0.77 |
| ▸ | LYN | P07948 | 2/20 | 0.77 |
| ▸ | PLK4 | O00444 | 1/20 | 0.77 |
| ▸ | DDX3X | O00571 | 1/20 | 0.77 |
| ▸ | GAK | O14976 | 1/20 | 0.77 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.77 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.77 |
| ▸ | CA12 | O43570 | 1/20 | 0.77 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.77 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.77 |
| ▸ | EGFR | P00533 | 1/20 | 0.77 |
| ▸ | CA1 | P00915 | 1/20 | 0.77 |
| ▸ | CA2 | P00918 | 1/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9485 | 0.97 | ABL1 (1.00) | ABL1BCRPDGFRAPDGFRBSRC | |
| SCHEMBL3866664 | 0.94 | ABL1 (0.94) | ABL1BCRPDGFRAPDGFRBSRC | |
| SCHEMBL3867814 | 0.91 | ABL1 (0.88) | ABL1BCRPDGFRAPDGFRBSRC | |
| Imatinib SCHEMBL8261481 | 0.90 | ABL1 (0.94) | ABL1BCRPDGFRAPDGFRBSRC | |
| SCHEMBL4897571 | 0.90 | ABL1 (0.86) | ABL1BCRPDGFRAPDGFRBSRC | |
| SCHEMBL4902292 | 0.89 | ABL1 (0.86) | ABL1BCRPDGFRAPDGFRBSRC | |
| SCHEMBL26358567 | 0.89 | ABL1 (0.85) | ABL1BCRPDGFRAPDGFRBSRC | |
| SCHEMBL3858318 | 0.89 | ABL1 (0.84) | ABL1BCRPDGFRAPDGFRBSRC | |
| SCHEMBL13038805 | 0.87 | ABL1 (0.82) | ABL1BCRPDGFRAPDGFRBSRC | |
| Imatinib SCHEMBL2236091 | 0.87 | ABL1 (1.00) | ABL1BCRPDGFRAPDGFRBSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0564409-B1 | Pyrimidin derivatives and process for their preparation | NOVARTIS AG (CH) | 2000-01-19 | — | — | EP | disclosed |
| EP-0564409-A1 | Pyrimidin derivatives and process for their preparation | CIBA-GEIGY AG (CH) | 1993-10-06 | — | — | EP | disclosed |