Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL2 | P60568 | 5/20 | 1.00 |
| ▸ | ESRRG | P62508 | 7/20 | 0.49 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.48 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.48 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.46 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.43 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.43 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8263091 | 0.87 | IL2 (0.77) | IL2ESRRGSTIM1ORAI1TP53 | |
| SCHEMBL8263094 | 0.85 | IL2 (0.74) | IL2ESRRGSTIM1ORAI1TP53 | |
| SCHEMBL5049887 | 0.83 | IL2 (0.70) | IL2TRPV1TLR7S1PR4NPY5R | |
| SCHEMBL5052756 | 0.82 | IL2 (0.69) | IL2TRPV1TLR7S1PR4NPY5R | |
| SCHEMBL5267756 | 0.81 | IL2 (0.79) | IL2ESRRGSTIM1ORAI1TP53 | |
| SCHEMBL5272202 | 0.79 | IL2 (0.67) | IL2ESRRGSTIM1ORAI1TP53 | |
| SCHEMBL5270188 | 0.78 | IL2 (0.63) | IL2 | |
| SCHEMBL5270372 | 0.78 | IL2 (0.63) | IL2ESRRGSTIM1ORAI1SMN1; SMN2 | |
| SCHEMBL5268580 | 0.78 | IL2 (0.65) | IL2ESRRGSTIM1ORAI1TP53 | |
| SCHEMBL8263090 | 0.77 | IL2 (0.63) | IL2ESRRGSTIM1ORAI1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8802721-B2 | Thiophene compounds for inflammation and immune-related uses | SYNTA PHARMACEUTICALS CORP. (US) | 2014-08-12 | — | — | US | disclosed |
| US-8802721-B2 | Thiophene compounds for inflammation and immune-related uses | SYNTA PHARMACEUTICALS CORP. (US) | 2014-08-12 | — | — | US | disclosed |
| WO-2006081389-A1 | THIOPHENE COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES | SYNTA PHARMACEUTICALS CORP. (US) | 2006-08-03 | — | — | WO | disclosed |