Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK5 | Q00535 | 3/20 | 0.48 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.48 |
| ▸ | CDK9 | P50750 | 2/20 | 0.48 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.48 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.47 |
| ▸ | WNT1 | P04628 | 3/20 | 0.47 |
| ▸ | CDK14 | O94921 | 12/20 | 0.46 |
| ▸ | CCNY | Q8ND76 | 12/20 | 0.46 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CDK4 | P11802 | 2/20 | 0.44 |
| ▸ | CDK2 | P24941 | 2/20 | 0.44 |
| ▸ | CASK | O14936 | 1/20 | 0.44 |
| ▸ | CDKL5 | O76039 | 1/20 | 0.44 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.44 |
| ▸ | CDK1 | P06493 | 1/20 | 0.44 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.44 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.44 |
| ▸ | MAK | P20794 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8212911 | 0.90 | CCNT1 (0.48) | CDK5CCNT1CDK9CDK5R1DYRK1A | |
| SCHEMBL955297 | 0.90 | DYRK1A (0.54) | DYRK1AWNT1HTR4CYP3A4CYP2D6 | |
| SCHEMBL30689622 | 0.89 | CDK5 (0.47) | CDK5CCNT1CDK9CDK5R1DYRK1A | |
| SCHEMBL24757744 | 0.89 | CDK14 (0.49) | CDK5CCNT1CDK9CDK5R1DYRK1A | |
| SCHEMBL22594205 | 0.88 | CDK14 (0.48) | CDK5CCNT1CDK9CDK5R1DYRK1A | |
| SCHEMBL1286714 | 0.87 | CDK5 (0.53) | CDK5CCNT1CDK9CDK5R1DYRK1A | |
| SCHEMBL22582205 | 0.87 | CDK5 (0.46) | CDK5CCNT1CDK9CDK5R1DYRK1A | |
| Bromide SCHEMBL22582181 | 0.87 | CDK14 (0.47) | CDK5CCNT1CDK9CDK5R1DYRK1A | |
| SCHEMBL30689624 | 0.87 | CDK5 (0.45) | CDK5CCNT1CDK9CDK5R1DYRK1A | |
| SCHEMBL22582208 | 0.86 | CDK5 (0.46) | CDK5CCNT1CDK9CDK5R1DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080306069-A1 | Pyrazole Derivatives for the Inhibition of CDK'S and GSK'S | ASTEX THERAPEUTICS LIMITED (UK) | 2008-12-11 | — | — | US | disclosed |
| US-20080306069-A1 | Pyrazole Derivatives for the Inhibition of CDK'S and GSK'S | ASTEX THERAPEUTICS LIMITED (UK) | 2008-12-11 | — | — | US | disclosed |
| WO-2006077414-A1 | PYRAZOLE DERIVATIVES FOR THE INHIBITION OF CDK' S AND GSK' S | ASTEX THERAPEUTICS LIMITED (GB) | 2006-07-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080306069-A1 | Pyrazole Derivatives for the Inhibition of CDK'S and GSK'S | GSK3A, CDK11A, CDK1 | CDK5 39/4885CCNT1 48/4885CDK9 15/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.