Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.65 |
| ▸ | BACE2 | Q9Y5Z0 | 13/20 | 0.65 |
| ▸ | CTSD | P07339 | 13/20 | 0.65 |
| ▸ | APP | P05067 | 1/20 | 0.57 |
| ▸ | REN | P00797 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3457392 | 0.85 | BACE1 (0.77) | BACE1BACE2CTSDAPPREN | |
| SCHEMBL4883787 | 0.81 | BACE1 (0.71) | BACE1BACE2CTSDAPPREN | |
| SCHEMBL3457576 | 0.79 | BACE1 (1.00) | BACE1BACE2CTSDAPP | |
| SCHEMBL4890598 | 0.78 | BACE1 (0.70) | BACE1BACE2CTSDAPPREN | |
| SCHEMBL13953459 | 0.77 | BACE1 (0.81) | BACE1BACE2CTSDAPPREN | |
| SCHEMBL13953457 | 0.77 | BACE1 (0.81) | BACE1BACE2CTSDAPPREN | |
| SCHEMBL13766644 | 0.76 | BACE1 (0.53) | BACE1BACE2CTSDAPP | |
| SCHEMBL13766660 | 0.76 | BACE1 (0.53) | BACE1BACE2CTSDAPP | |
| SCHEMBL13953600 | 0.74 | BACE1 (0.79) | BACE1BACE2CTSDAPPREN | |
| SCHEMBL13953601 | 0.74 | BACE1 (0.79) | BACE1BACE2CTSDAPPREN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2264036-A1 | Amino-imidazolones for the inhibition of beta-secretase | Wyeth LLC (Formerly Known As Wyeth) (US) | 2010-12-22 | — | — | EP | disclosed |
| WO-2006076284-A2 | AMINO-IMIDAZOLONES FOR THE INHIBITION OF ß-SECRETASE | WYETH (US) | 2006-07-20 | — | — | WO | disclosed |